Single-pass tangential flow filtration (SPTFF) is revolutionizing how tangential flow filtration (TFF) is implemented in biotech, vaccine, blood plasma and other applications. Pall has now made it even easier to implement this breakthrough patented technology into your process. As with the original Cadence SPTFF modules, the Cadence Inline Concentrator (ILC) allows direct flow through in-process volume reduction and can be implemented into a process system or operated as a stand alone unit.

This exciting new technology leads to economic and practical benefits, including:

• Ability to couple the concentration of product before or after other downstream processing (DSP) steps, consequently optimizing other steps and reducing in-process pool tank volumes.
• Continuous processing in DSP
• Easy integration of the assembled module, allowing plug and play
• Potential reduction of product damage or aggregation due to reduced residence time and shear exposure.

The preassembled Cadence ILC modules do not need a holder. Once the feed port is connected to a pressurized feed source, the module is ready for use. The built-in resistor in the retentate manifold eliminates the need for downstream instrumentation and allows volume reduction of 2 to 4X (or higher), depending on the application.

Similar to other Cadence SPTFF devices, the Cadence ILC utilizes standard Pall T-Series cassettes as the building blocks for the module. These modules are offered with either Delta regenerated cellulose or Omega polyethersulfone (PES) 10 kDa or 30 kDa membranes providing the high flux, high selectivity and low protein binding characteristics associated with these membranes. They are available in a range of size formats to accommodate various processing volumes.

These products utilize proprietary technology, as well as technology licensed from SPF Innovations, and may be covered by one or more patents. See pall.com/patents.

Optimize Economic and Operational Benefits

Enhance downstream processing to increase capacity and reduce costs

Cadence ILC modules can help to eliminate or reduce the size of intermediate storage tanks and associated cleaning of tanks when used for in-process volume reduction before or after existing steps.

Enable in-process volume reduction

Depending on the initial concentration and product characteristics, a volume reduction of 2 to 4X (or higher) can be achieved with minimal instrumentation or system requirements.

Optimize processing of highly shear-sensitive products

Processing with the Cadence ILC results in only one pass through the pump and module, reducing shear exposure. For products sensitive to pumping, the pump can be completely eliminated by using pressurized vessels to flow the process fluid through the module. Further benefits are achieved by eliminating any mixing or foaming issues associated with the feed tank.

No holder required

Cadence ILC modules are provided assembled, and the cassettes and manifolds are pre-torqued between two end plates so that no extra holder is required.

Benefits include:

• Easy connection to a pressure source, like a pump or pressure vessel
• Simplified in-process volume reduction
• Continuous processing enabled by process coupling
• The module feed, retentate and permeate ports are easily connected to the appropriate outlets using clearly marked ports

Product Platform

Innovative SPTFF processing takes place within the Cadence ILC modules. The modules incorporate Pall’s proven T-series cassettes with Delta or Omega membrane and are available in different formats to accommodate various processing volumes (see ordering information).